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Department of Evolutionary Biology and Environmental Studies

Aleks Nivina

Table of contents

Research interests

Natural product biosynthesis, modular polyketide synthases, antibiotic biosynthesis, antibiotic resistance, enzyme evolution, evolutionary innovation, DNA recombination and gene conversion

CV

Education and professional positions

2023 - present Junior Group leader (SNSF Ambizione fellow), Department of Evolutionary Biology and Environmental Studies, University of Zurich, Switzerland
2022 - 2023 Scientist, Molecular and Cell Biology Group, Codexis Inc., San Carlos, California, USA
2017 - 2022 Postdoctoral fellow, Chemistry Department, Stanford University, California, USA
2017 Postdoctoral Fellow, Genetics Department, Institut Pasteur, Paris, France
2012 - 2016 Ph.D. in Interdisciplinary Biology, Genetics Department, Institut Pasteur, Paris, France
2011 - 2012 M.Sc. in Systems and Synthetic Biology, Centre for Interdisciplinary Research, Paris Descartes University, France
2006 - 2015 Pharm.D. in Pharmaceutical Research, Faculty of Pharmacy, Paris Descartes University, France

See complete publication list on Google Scholar: list.

Selected publications

  • Nivina A.*, Paredes SH.*, Fraser HB., Khosla C. (2021). GRINS: Genetic elements that recode assembly-line polyketide synthases and accelerate their diversification. PNAS, 118(26):e2100751118 DOI: 10.1073/pnas.2100751118
  • Nivina A., Grieb MS., Loot C., Bikard D., Cury J., Shehata L., Bernardes J., Mazel D. (2020). Structure-specific DNA recombination sites: Design, validation, and machine learning-based refinement. Science Advances, 6(30):eaay2922 DOI: 10.1126/sciadv.aay2922
  • Nivina A., Yuet KP., Hsu J., Khosla C. (2019). Evolution and Diversity of Assembly-Line Polyketide Synthases. Chemical Reviews, 119(24):12524-12547. DOI: 10.1021/acs.chemrev.9b00525
  • Escudero JA., Nivina A., Kemble HE., Loot C., Tenaillon O., Mazel D. (2020). Primary and promiscuous functions coexist during evolutionary innovation through whole protein domain acquisitions. eLife, 9:e58061. DOI: 10.7554/eLife.58061
  • Loot C.*, Nivina A.*, Cury J., Escudero JA., Ducos-Galand M., Bikard D., Rocha EPC., Mazel D. (2017). Differences in Integron Cassette Excision Dynamics Shape a Trade-Off between Evolvability and Genetic Capacitance. mBio, 8(2):e02296-16 . DOI: 10.1128/mBio.02296-16
  • Escudero JA., Loot C., Parissi V., Nivina A., Bouchier C., Mazel D. (2016). Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation. Nature Communications, 7:10937. DOI: 10.1038/ncomms10937

Weiterführende Informationen

Aleks Nivina

Junior group leader

Department of Evolutionary Biology and Environmental Studies
University of Zurich
Winterthurerstrasse 190
8057 Zurich

Office: Y27-J-46