Aleks Nivina
Table of contents
Research interests
Natural product biosynthesis, modular polyketide synthases, antibiotic biosynthesis, antibiotic resistance, enzyme evolution, evolutionary innovation, DNA recombination and gene conversion
CV
Education and professional positions
| 2023 - present | Junior Group leader (SNSF Ambizione fellow), Department of Evolutionary Biology and Environmental Studies, University of Zurich, Switzerland |
| 2022 - 2023 | Scientist, Molecular and Cell Biology Group, Codexis Inc., San Carlos, California, USA |
| 2017 - 2022 | Postdoctoral fellow, Chemistry Department, Stanford University, California, USA |
| 2017 | Postdoctoral Fellow, Genetics Department, Institut Pasteur, Paris, France |
| 2012 - 2016 | Ph.D. in Interdisciplinary Biology, Genetics Department, Institut Pasteur, Paris, France |
| 2011 - 2012 | M.Sc. in Systems and Synthetic Biology, Centre for Interdisciplinary Research, Paris Descartes University, France |
| 2006 - 2015 | Pharm.D. in Pharmaceutical Research, Faculty of Pharmacy, Paris Descartes University, France |
See complete publication list on Google Scholar: list.
Selected publications
- Nivina A.*, Paredes SH.*, Fraser HB., Khosla C. (2021). GRINS: Genetic elements that recode assembly-line polyketide synthases and accelerate their diversification. PNAS, 118(26):e2100751118 DOI: 10.1073/pnas.2100751118
- Nivina A., Grieb MS., Loot C., Bikard D., Cury J., Shehata L., Bernardes J., Mazel D. (2020). Structure-specific DNA recombination sites: Design, validation, and machine learning-based refinement. Science Advances, 6(30):eaay2922 DOI: 10.1126/sciadv.aay2922
- Nivina A., Yuet KP., Hsu J., Khosla C. (2019). Evolution and Diversity of Assembly-Line Polyketide Synthases. Chemical Reviews, 119(24):12524-12547. DOI: 10.1021/acs.chemrev.9b00525
- Escudero JA., Nivina A., Kemble HE., Loot C., Tenaillon O., Mazel D. (2020). Primary and promiscuous functions coexist during evolutionary innovation through whole protein domain acquisitions. eLife, 9:e58061. DOI: 10.7554/eLife.58061
- Loot C.*, Nivina A.*, Cury J., Escudero JA., Ducos-Galand M., Bikard D., Rocha EPC., Mazel D. (2017). Differences in Integron Cassette Excision Dynamics Shape a Trade-Off between Evolvability and Genetic Capacitance. mBio, 8(2):e02296-16 . DOI: 10.1128/mBio.02296-16
- Escudero JA., Loot C., Parissi V., Nivina A., Bouchier C., Mazel D. (2016). Unmasking the ancestral activity of integron integrases reveals a smooth evolutionary transition during functional innovation. Nature Communications, 7:10937. DOI: 10.1038/ncomms10937
