Constraint
Variation Mahadevan-Schilling Flux Intervals
This process is used to compute the Mahadevan-Schilling
intervals of fluxes in a stoichiometric network [1].
All reactions in the provided network must be irreversible, or else an
error will be reported. The following steps are executed during this
process:
1. |
If a constraints file is
specified, the flux constraints it contains are applied. |
2. |
The next set of flux constraints contained
in the constraint variation file are applied. These
constraints will override any pre-existing constraints for the
specified fluxes (or linear combinations of fluxes). |
3. |
The flux intervals are computed, and the
results are written to the next line of the specified output file. |
4. |
All flux constraints are restored to the
state achieved immediately after Step 1. |
5. |
If another set of flux constraints is
present in the constraint variation file, Steps 2-5 are
repeated. |
The way in which flux intervals are computed in Step 3 is the
same as that used in the Mahadevan-Schilling
Flux Intervals process.
References
1. |
Mahadevan R., Schilling C. H. (2003) The effects of
alternate optimal solutions in constraint-based genome-scale
metabolic models. Metab. Eng., 5(4): 264-76. |
Here is the set of keywords this process understands, along
with a description of their possible corresponding values. See the command line
documentation for more information about keyword-value pairs.
|