Mahadevan-Schilling
Flux Intervals
This process is used to compute the Mahadevan-Schilling
intervals of fluxes in a stoichiometric network [1].
All reactions in the provided network must be irreversible, or else an
error will be reported. Before computing the intervals of each flux,
the fluxes of reactions participating in steady state cycles are capped.
The following steps are undertaken to compute these intervals:
1. |
The maximum flux is computed for each
reaction for which a flux
cap was provided. |
2. |
For each flux determined to be unbounded
in Step 1, its upper bound is defined using its flux cap. |
3. |
The minimum flux of each reaction in the
stoichiometric network is computed. |
4. |
The maximum flux of each reaction in the
stoichiometric network is computed. |
5. |
The minimum and maximum fluxes from Steps
3 and 4 are written to the specified output file. |
References
1. |
Mahadevan R., Schilling C. H. (2003) The effects of
alternate optimal solutions in constraint-based genome-scale
metabolic models. Metab. Eng., 5(4): 264-76. |
Here is the set of keywords this process understands, along
with a description of their possible corresponding values. See the command line
documentation for more information about keyword-value pairs.
|