Macarena Toll-Riera

Link to Research Group page (Dr. Macarena Toll-Riera)

Link to Research Group page (Prof. Dr. Andreas Wagner)

Research Interests

Evolutionary innovation, mutational robustness, protein stability, gene duplication, protein evolutionary rates, how new genes are originated, bacterial evolution, plasmid paradox, experimental evolution, next generation-sequencing.


Education and Professional Positions

2016 - present Ambizione fellow, Department of Evolutionary Biology and Environmental Studies, University of Zurich, Switzerland
2014 - 2016 Post-doctoral researcher, Department of Evolutionary Biology and Environmental Studies, University of Zurich, Switzerland
2013 - 2014 Post-doctoral researcher, Department of Zoology, University of Oxford, United Kingdom
2011 Visiting Ph.D. student, Department of Biology, University of Pennsylvania, United States of America
2008 - 2012 Ph.D. student, Universitat Pompeu Fabra, Spain
2007 - 2008 M.Sc. in Human Biology and Evolution, Universitat de Barcelona, Spain
2002 - 2007 B.Sc. in Biology, Universitat Pompeu Fabra, Spain

Selected Publications

  • Toll-Riera M.*, San Millan A.*, Wagner A., MacLean RC. (2016) The genomic basis of metabolic evolutionary innovation in Pseudomonas aeruginosa. PLoS Genet. 12(5):e1006005. DOI: 10.1371/journal.pgen.1006005
  • Qin Q., Toll-Riera M., Heilbron K., Preston GM. and MacLean RC. (2016) The genomic basis of adaptation to the fitness cost of rifampicin resistance inPseudomonas aeruginosa. Proceedings of the Royal Society of London, Series B: Biological Sciences, 283(1822):20152452. DOI: 10.1098/rspb.2015.2452
  • San Millan A.*, Toll-Riera M.*, Qin Q., MacLean RC. (2015) Interactions between horizontally acquired genes create a fitness cost in Pseudomonas aeruginosa. Nat Commun. 6:6845. DOI: 10.1038/ncomms7845
  • San Millan A., Peña-Miller R.*, Toll-Riera M.*, Halbert ZV., McLean AR., Cooper BS., MacLean RC. (2014) Positive selection and compensatory adaptation interact to stabilize non-transmissible plasmids. Nat Commun. 5:5208. DOI: 10.1038/ncomms6208
  • Heilbron K., Toll-Riera M., Kojadinovic M., MacLean RC. (2014) Fitness is strongly influenced by rare mutations of large effect in a microbial mutation accumulation experiment. Genetics. 197(3):981-90. DOI: 10.1534/genetics.114.163147
  • Toll-Riera M., Albà MM. (2013) Emergence of novel domains in proteins. BMC Evol Biol. 13:47. DOI: 10.1186/1471-2148-13-47
  • Toll-Riera M., Bostick D., Albà MM.*, Plotkin JB.*. (2012) Structure and age jointly influence rates of protein evolution.PLoS Comput Bio. 8(5):e1002542. DOI: 10.1371/journal.pcbi.1002542
  • Toll-Riera M., Radó-Trilla N., Martys F., Albà MM. (2012) Role of low- complexity sequences in the formation of novel protein coding sequences. Mol Biol Evol. 29(3):883-6. DOI: 10.1093/molbev/msr263
  • Toll-Riera M., Laurie S., Albà MM. (2011) Lineage-specific variation in intensity of natural selection in mammals. Mol Biol Evol. 28(1):383-98. DOI: 10.1093/molbev/msq206
  • Toll-Riera M., Bosch N., Bellora N., Castelo R., Armengol L., Estivill X., Albà MM. (2009) Origin of primate orphan genes: a comparative genomics approach. Mol Biol Evol. 26(3):603-12. DOI: 10.1093/molbev/msn281