Yolanda Schaerli-Renggli

Research Interests

My research focusses on the general design principles of gene regulatory networks. Examples of questions I am asking are: In how many different ways can one task be achieved by different gene regulatory networks? What are the mechanisms of the different solutions? Do we find all these networks in nature? How do they evolve? How robust are they? To answer these questions, I build gene regulatory networks using the tools of synthetic biology and analyse them with a combination of wet lab experiments and computational modelling.


Education and Professional Positions

2014 - present SNSF Ambizione fellow, Department of Evolutionary Biology and Environmental Studies, University of Zurich, Switzerland
2012 - 2014 Marie Curie post-doctoral fellow, EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain
2011 - 2012 SNSF post-doctoral fellow, EMBL/CRG Systems Biology Research Unit, Centre for Genomic Regulation (CRG), Barcelona, Spain
2007 - 2010 Ph.D. researcher, Departments of Biochemistry and Chemistry, University of Cambridge, UK
2002 - 2006 M.Sc. in Biochemistry and Molecular Biology, ETH Zurich, Switzerland

Selected Publications

  • Baumstark R., Hänzelmann S., Tsuru S., Schaerli Y., Francesconi M., Mancuso FM., Castelo R., Isalan M. (2015). The propagation of perturbations in rewired bacterial gene networks. Nature Communications, 6:10105. DOI: 10.1038/ncomms10105
  • Schaerli Y., Gili M., Isalan M. (2014). A split intein T7 RNA polymerase for transcriptional AND-logic. Nucleic Acids Research, 42(19):12322-12328. DOI: 10.1093/nar/gku884
  • Schaerli Y., Munteanu A., Gili M., Cotterell J., Sharpe J., Isalan M. (2014).A unified design space of synthetic stripe-forming networks. Nature Communications, 5:4905. DOI: 10.1038/ncomms5905
  • Fischlechner M., Schaerli Y., Mohamed M., Patil S., Abell C., Hollfelder F., (2014). Evolution of enzyme catalysts caged in biomimetic gel-shell beads. Nature Chemistry, 6(9):791-796. DOI: 10.1038/nchem.1996
  • Diamante L., Gatti-Lafranconi P., Schaerli Y., Hollfelder F. (2013). In vitro affinity screening of protein and peptide binders by megavalent bead surface display. Protein Eng Des Sel. 26(10):713-24. DOI: 10.1093/protein/gzt039
  • Schaerli Y., Isalan M. (2013). Building synthetic gene circuits from combinatorial libraries: screening and selection strategies. Mol. BioSyst. 9(7):1559-67. DOI: 10.1039/c2mb25483b
  • Schaerli Y., Stein V., Spiering MM., Benkovic SJ., Abell C., Hollfelder F. (2010). Isothermal DNA amplification using the T4 replisome: circular nicking endonuclease-dependent amplification and primase-based whole-genome amplification. Nucleic Acids Res. 38(22):e201. DOI: 10.1093/nar/gkq795
  • Theberge A., Courtois F., Schaerli Y., Fischlechner M., Abell C., Hollfelder F., Huck WTS. (2010). Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology. Angew. Chem. Int. Ed. Engl. 9;49(34):5846-68. DOI: 10.1002/anie.200906653
  • Schaerli Y., Hollfelder F. (2009). The potential of microfluidic water-in-oil droplets in experimental biology. Mol. BioSyst. 5: 1392–1404. DOI: 10.1039/B907578J
  • Robinson, T., Schaerli Y., Wootton RC., Hollfelder F., Dunsby C., Baldwin GS., Neil MAA., French PMW., deMello AJ. (2009). Removal of background signals from fluorescence thermometry measurements in PDMS microchannels using fluorescence lifetime imaging. Lab Chip. 9: 3437–3441. DOI: 10.1039/B913293G
  • Schaerli Y., Wootton RC., Robinson T., Stein V., Dunsby C., Neil MAA., French PMW., deMello AJ., Abell C., Hollfelder F. (2009). Continuous-flow polymerase chain reaction of single-copy DNA in microfluidic microdroplets. Anal. Chem. 81(1): 302-306. DOI: 10.1021/ac802038c