Our research integrates population genetic theory, methods development, and application of these to genomic data in order to answer questions at the interface of demography, selection, and recombination. These include the importance of selection against past or ongoing gene flow in speciation, the identification of the underlying genes, and the accumulation and medical consequences of deleterious mutations as a function of demographic history. The overall goal of this work is to understand the evolution and maintenance of genetic diversity in natural populations as well as in our own species.
- Inferring the timing and strength of gene flow and selection
- Understanding the genetic basis of adaptation and speciation
- Quantifying the impact of demography on natural selection.